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NEW PRODUCT

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3781
9,417,108

: 7375

CLARIOstar

: may-doc-phien-da-nang-clariostar

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CLARIOstar
Versatile, high-performance microplate reader with monochromators, spectrometer, and filters

The CLARIOstar® is BMG LABTECH’s most flexible microplate reader, equipped with revolutionary LVF monochromator technology. Thanks to the triple technology, monochromators, filters, and spectrometer, it does not compromise on sensitivity or flexibility. As well as its high performance in all detection modes, the CLARIOstar’s versatility also makes it ideal for assay development.
Anything is possible. Any wavelength. Any bandwidth. Any assay.
NEW: Now available with an Atmospheric Control Unit for all your live cell-based assays!

Details
The CLARIOstar® is a multimode microplate reader with advanced LVF Monochromators™, highly sensitive filters, and an ultra-fast UV/Vis spectrometer. It is a modular microplate reader with up to eight different detection modes: fluorescence intensity (including FRET), fluorescence polarization, luminescence (including BRET), UV/Vis absorbance, time-resolved fluorescence (including TR-FRET), and AlphaScreen®/AlphaLISA®
Features:

Increased sensitivity over conventional monochromators
Continuously adjustable bandwidths (8 to 100 nm) and wavelengths (320 to 850 nm)
Combined use of LVF monochromators™ and filters in the same measurement
Full-spectrum UV/Vis absorbance measurements in less than 1 second
Dedicated, high-energy laser for AlphaScreen®/AlphaLISA®/AlphaPlexTM
Automated focal Z-height adjustment for top and bottom readings
Includes multi-user control and MARS data analysis software with integrated fluorophore library
NEW: ACU compatible for O₂ and CO₂ control
Compatible with LVis Plate and stacker

001, DNA measurements in low volume samples, microplates and cuvettes on the SPECTROstar Nano -

245, Fluorescence Intensity Transcreener® assay used to detect ADP on the CLARIOstar® -

244, The CLARIOstar® surpasses the certification needed for the Transcreener® ADP2 FP assay -

243, Dual Luciferase Reporter (DLR) Assay Certification on the PHERAstar FS -

242, Low-volume protein measurements (280nm): Validating the LVis Plate over many concentrations -

241, Molecular Beacon based helicase assays on the FLUOstar Omega -

240, A high-throughput, homogeneous, FRET-based assay to detect bacterial membrane-bound enzyme (MraY) activity -

239, Dual Luciferase Reporter (DLR) Assay Certification on the CLARIOstar® using LVF monochromators™ -

237, Lonza’s Kinetic Kit for Endotoxin Detection Using the FLUOstar OPTIMA and MARS Data Analysis -

236, Identification and characterisation of novel positive allosteric modulators of the Galanin 2 Receptor -

235, Three assays in one well: Antimalarial compound library screening using the FLUOstar Omega -

234, Real-time fluorescence assay for monitoring transglutaminase activity -

233, Simultaneous dual-emission detection of luciferase reporter assays -

232, Real-Time Quaking Induced Conversion Assay for Prion Seeding -

231, Label-Free Kinetic Measurements Using SoPRano™ Gold Nano Rods (GNRs) and a Spectrometer Microplate Reader -

230, Label-Free SoPRano™ Gold Nano-Rod (GNR) Assays on a Spectrometer-Based Microplate Reader -

228, Biocolor's APOPercentage Apoptosis Assay™ on BMG LABTECH's SPECTROstar Nano plate reader -

227, Quantifying Fluorescent Ligand Binding to GPCRs in Live Cells using the PHERAstar FS - a new format for HTS -

226, A New Way to Test the Free Amino Nitrogen Content in Alcoholic Beverages with the SPECTROstar Nano -

225, Methyltransferase, Acetyltransferase, Kinases, and GTPases Can All Be Measured with Transcreener® Assays -

224, Assessing pancreatic trypsin activity using the POLARstar Omega Microplate Reader -

220, A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1) -

219, Assessment of Extracellular Acidification using a Fluorescence-Based Assay -

215, Miniaturised Platelet Aggregation Assays using the NOVOstar Microplate Reader -

214, Quantitative, High- Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability -

213, The ELISAONE™ assay performed on the POLARstar Omega from BMG LABTECH -

212, Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules -

211, Measure femtogram quantities of dsDNA on the BMG LABTECH PHERAstar Plus -

210, An AlphaScreen® SureFire® Phospho-ERK1/2 assay performed on BMG LABTECH's POLARstar Omega -

209, GPCR Activation is Measured with Cisbio’s cAMP and IP-One HTRF® HTplex™ Cell-based Assay -

208, A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition -

207, Assessing Microbial Metabolism Using A Simple ‘Mix & Measure’ Oxygen Consumption Assay -

206, Cellular Dopamine and Intracellular Calcium Signaling Using the Next Generation HTS Microplate Reader -

205, Membrane Fluidity Measurements Using UV Fluorescence Polarization and the POLARstar Omega -

204, Analysis of migration using the Oris(TM) Cell Migration Assay-TriCoated kit on the POLARstar Omega -

203, Enzyme Kinetic Measurements for a Combinatorial Library of Inhibitors of Pseudomonas Elastase -

202, Promega's ADP-Glo™ Kinase Assay performed on BMG LABTECH's PHERAstar FS and POLARstar Omega -

201, The Transcreener® ADP2 FI Assay performed on PHERAstar and Omega microplate readers -

199, Monitoring Bacterial Cell-to-Cell Communication “Quorum sensing” Using FLUOstar OPTIMA -

197, ORAC Assay Performed on the POLARstar Omega and PHERAstar FS microplate reader -

196, Using Intrinsic Tryptophan Fluorescence to Measure Heterotrimeric G-Protein Activation -

195, alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA -

194, FRET-based screening for potential modulators of the Gαi1 protein/GoLoco interaction -

192, A DELFIA® time-resolved fluorescence cell-mediated cytotoxicity assay performed on the PHERAstar -

191, High-Throughput Monitoring of Bacterial Growth at Elevated Hydrostatic Pressure on the FLUOstar OPTIMA -

190, Homogeneous IgG AlphaLISA® assay performed on BMG LABTECH’s PHERAstar Plus -

189, High-Throughput Method for Dual Assessment of Antifungal Activity and Growth Kinetics Using a FLUOstar Omega -

188, A Leukocyte Adhesion Assay Performed on BMG LABTECH’s FLUOstar OPTIMA -

187, Application of the Amplifluor® SNPs Genotyping System using a FLUOstar OPTIMA microplate reader -

186, AlphaScreen® Phosphotyrosine Assay Performed on a FLUOstar Omega and a POLARstar Omega -

185, Enzyme kinetic measurements performed on BMG LABTECH's FLUOstar OPTIMA -

184, Multiplex Analysis of Inflammatory Cytokines from Primary Human Macrophages using a FLUOstar Omega -

183, New Transcreener® ADP2 FP Assay performed on BMG LABTECH's POLARstar Omega Microplate Reader -

182, New Transcreener® ADP2 FP Assay performed on BMG LABTECH´s PHERAstar Plus HTS Microplate Reader -

180, High-throughput protein-DNA affinity measurements using fluorescence anisotropy -

179, Fluorometric determination of extracellular enzyme activities in peat using the FLUOstar OPTIMA -

178, Reaction optimization by parallel kinetic studies with the FLUOstar Omega -

177, HTRF® IP-One Terbium-based assay performed on BMG LABTECH´s PHERAstar Plus -

176, Rapid ultra-sensitive isothermal DNA detection using RPA technology and the POLARstar OPTIMA -

175, Measuring Mitochondrial Membrane Potential using the FLUOstar Omega Microplate Reader -

173, Predictor™ hERG Fluorescence Polarization Assay Kit performed on the PHERAstar/PHERAstar Plus -

172, Dual luciferase assay to assess the replication of the hepatitis C virus subgenomic replicon -

171, Evaluation of PARP Inhibitors: Performed on BMG LABTECH’s FLUOstar Omega -

169, Old Assays, New Instrument: ELISA; NADH and NADPH Conversion; DNA and Protein Quantitation -

168, DNA Absorbance Quantitation Using BMG LABTECH´s POLARstar Omega Microplate Reader -

167, Comparison of Thioredoxin Activity in Cortical Neurons and Glial Cells using the FLUOstar OPTIMA -

166, Molecular Probes® NanoOrange® Assay Performed on BMG LABTECH FLUOstar OPTIMA Microplate Reader -

165, Dual Luciferase Reporter (DLR) Assay Certification on the Omega Series of Readers -

164, Use of the FLUOstar OPTIMA Microplate Reader to Monitor Amyloid Formation -

163, SUMO FRET-based Assays Performed on BMG LABTECH’s NOVOstar -

159, High-Throughput Method for Dynamic Measurements of Cellular Viability Using a FLUOstar OPTIMA -

156, Internalisation of Fluorescently Labelled Phagocytosis Targets Quantified by the FLUOstar OPTIMA -

153, Detection of Tyrosine Kinase Activity Using the PHERAstar in AlphaScreen® Mode -

170, Detection of NADH and NADPH with the Omega’s High Speed, Full UV/Vis Absorbance Spectrometer -

162, Investigation of the Stereoselectivity of an Anti-Amino Acid Antibody Utilizing Tryptophan Fluorescence -

158, Bradford Assay Performed on BMG LABTECH´s FLUOstar Omega with new Evaluation Software -

154, Cisbio's HTRF® Cortisol assay performed on the PHERAstar -

152, Transcreener® ADP Fluorescence Polarization Assay Performed on the PHERAstar -

151, Promega’s P450-Glo™ Luminescent Cytochrome P450 Assay Using the FLUOstar OPTIMA -

148, ORAC Assay on the FLUOstar OPTIMA to Determine Antioxidant Capacity -

147, LUMIstar Microplate Reader in the production and quality control for ROTAS on-site test kit reagents -

146, Size-selective assessment of tight junction paracellular permeability using fluorescently labelled dextrans -

145, Plasso EpranEx™ ready to use heparin-binding plate with the FLUOstar OPTIMA plate reader -

144, Analysis of Prostate Tumour Cell Invasion Using BD FluoroBlok™and FLUOstar OPTIMA -

143, Study of GPCR pharmacology using the DiscoveRx HitHunter™ cAMP HS assay on the FLUOstar OPTIMA -

142, HitHunter™ IP3 Assay for GPCR Screening using the PHERAstar -

141, ADP Hunter™ Assay for HTS of Kinase Inhibitors using the PHERAstar -

140, High-Throughput Determination of Bacterial Growth Kinetics using a FLUOstar OPTIMA -

139, Promega’s Multiplexed Luciferase Reporter and Cell Viability Assays performed on the PHERAstar -

138, Promega’s Multiplexed Cell Viability and Apoptosis Assays performed on the PHERAstar -

137, HTRF® IP-One Assay Performed on the PHERAstar and RUBYstar* Plate Readers -

136, LUX Biotechnology GLOWELL™ luminometry standards on the POLARstar OPTIMA -

135, Protein Aggregation Monitoring on the FLUOstar OPTIMA Microplate Reader -

132, Development of a post-reaction derivatisation and fluorescence assay for 2-OG dependent dioxygenases -

131, Cambrex PKLight™ Protein Kinase Assay on the PHERAstar Plate Reader -

130, Cambrex Bio Science MycoAlert™ Assay on the LUMIstar plate reader -

128, High-Throughput Measurement of Protein Stability using a FLUOstar OPTIMA Microplate Reader -

127, A Novel PI 3-Kinase Assay Utilising HTRF® Technology on the RUBYstar -

126, PHERAstar: A Next Generation Multimode Plate Reader for Sophisticated HTS Assays -

124, Identification of False Positives in an FP (Fluorescence Polarization) Screen -

123, Ion Channel Assay Development using Invitrogen’s FRET-based Voltage Sensor Probes -

122, Use of CyDye Fluors for Improved FRET Protease Assays on the POLARstar Microplate Reader -

119, Fluorescence Polarization Discriminates Green Fluorescent Protein from Interfering Autofluorescence -

118, BRET assays performed on the FLUOstar OPTIMA -

112, Use of the LUMIstar to Monitor the Production of Free Radicals by Leukocytes in Diluted Blood -

111, Chemiluminescence Measurement of the Generation of Reactive Oxygen Species -

106, Inhibitory Effect of Terbinafine on Reactive Oxygen Species (ROS) Generation by Candida albicans -

105, Fluorescence analysis of reactive oxygen species by six isolates of Aspergillus Fumigatus -

103, Molecular Probes PicoGreen assay performed on BMG LABTECH POLARstar OPTIMA plate reader -

246, Optimizing the PicoGreen® Assay on BMG LABTECH’s CLARIOstar® multimode microplate reader using LVF Monochromators™ -

254, Tryptophan quantification using UV fluorescence measurements on the CLARIOstar® multi-mode microplate reader -

253, Real time calcium flux measurements in iPSC derived 3D heart tissues -

255, Detecting Sclerostin-LRP5/6 interaction using the CLARIOstar® and LVF-Monochromator -

256, Protein-Ligand binding measurements using fluorescence polarization -

258, Detection of PARP-induced ADP-ribosylation using the CLARIOstar® microplate reader -

257, Looking for a strong promoter for Physcomitrella patens -

259, Using CLARIOstar® fluorescence polarization detection to perform hERG Predictor™ assay -

278, The new Atmospheric Control Unit (ACU) for the CLARIOstar® provides versatility in long term cell-based assays -

280, The OxiSelect Cellular Antioxidant Assay (CAA) on the FLUOstar Omega -

281, Detecting Mycoplasma Cell Culture Contamination Using the CLARIOstar® Microplate Reader -

Detection Modes

Fluorescence Intensity
FRET
Fluorescence Polarization
AlphaScreen®/AlphaLISA®/AlphaPlexTM
Luminescence (flash and glow)
BRET
Time-Resolved Fluorescence - including TR-FRET
UV/Vis absorbance spectra

Measurement Modes

Top and bottom reading
Endpoint and kinetic measurements
Sequential multi-excitation measurements
Sequential multi-emission measurements
Spectral scanning (fluorescence, luminescence, absorbance)
Ratiometric measurements
Well scanning

Microplate Formats

6- to 1536-well plates, user-definable
LVis Plate with 16 low volume microspots (2 μL)

Microplate Carrier

Robot compatible

Light Sources

High energy xenon flash lamp
Dedicated laser for AlphaScreen®/AlphaLISA®/AlphaPlexTM

Detectors

Low noise photomultiplier tube
CCD spectrometer

Wavelength Selection

Dual Linear Variable Filter (LVF) Monochromators™

Linear Variable Dichroic Mirror
Separates Ex & Em LVF Monochromators
Optical filters:
Ex and Em slides hold 4 filters each
LVF Monochromators + optical filters
Use one for Ex and the other for Em
UV/Vis absorbance spectrometer:
Full spectra or 8 distinct wavelengths in < 1 sec/well

Optical Filters

Excitation and emission slides for 4 filters each

Optical Path Guides

Top and bottom: Enclosed, free-air optical light path guided by motor-driven mirrors and dichroics

Z-Adjustment

Automatic focal height adjustment (0.1 mm resolution)

Spectral Range

Filters	240 - 750 nm or 240 - 900 nm for FI, FP, TRF 240 - 750 nm for LUM
LVF Monochromators™	320 - 850 nm for FI 320 - 750 nm for LUM
Linear Variable Dichroic	340 - 740 nm for FI, LUM
Spectrometer	220 - 1000 nm for ABS

Sensitivity*

FI Filters (top)	< 0.15 pM (< 3 amol/well Fluorescein, 384sv, 20 μL)
FI Filters (bottom)	< 1.0 pM (< 50 amol/well Fluorescein, 384g, 50 μL)
FI Monochromator (top)	< 0.35 pM (< 7 amol/well Fluorescein, 384sv, 20 μL)
FI Monochromator (bottom)	< 3.0 pM (< 150 amol/well Fluorescein, 384g, 50 μL)
FP	< 0.5 mP SD at 1 nM Fluorescein (384sv, 20 μL)
HTRF® (black and white microplates)	Reader Control Kit (Eu) after 18h (384sv, 20 μL) Delta F > 880 % (High Calibrator) Delta F > 30 % (Low Calibrator)
TRF	< 20 fM Europium, 384, 80 μL
LUM	< 0.4 pM (< 8 amol/well ATP, 384sv, 20 μL) Dynamic Range: 9 decades
AlphaScreen® with Laser	< 5 pM (< 100 amol/well P-Tyr-100, 384sv, 20 μL)
ABS with Spectrometer	Full spectrum captured in < 1 s / well Selectable spectral resolution: 1, 2, 5, and 10 nm OD range: 0 - 4 OD Accuracy: < 1% at 2 OD Precision: < 0.5% at 1 OD and < 0.8% at 2 OD

Read Times

Flying mode (1 flash)	8 s (96), 15 s (384), 28 s (1536)
10 flashes	19 s (96), 57 s (384), 3 min 4 s (1536)

Reagent Injection

Up to 2 built-in reagent injectors
Individual injection volumes for each well: 3 to 500 µL (optionally up to 2 mL)
Variable injection speed up to 420 µL / s
Reagent back flushing

Shaking

Linear, orbital, and double-orbital with user-definable time and speed

Incubation

+3 °C above ambient up to 45 °C or 65 °C

The upper heating plate of the incubation chamber operates at 0.5 °C more than the lower plate. This prevents condensation build-up on the lid or sealer.

Software

Integrated fluorophore library
Multi-user Reader Control and MARS Data Analysis Software included
FDA 21 CFR Part 11 compliant

Dimensions

Width: 45 cm, depth: 51 cm, height: 40 cm; weight: 32 kg

Optional Accessories

LVis Plate

Sample Capacity: Sixteen separate microdrop wells for 2 µL samples; One standard cuvette position for up to 1 mL samples.
Quality Control Internal Standards (optional): Four NIST traceable optical density filters (approximate values of 0.1, 0.3, 0.6 and 1.0 OD); One holmium oxide filter for wavelength accuracy
Dimensions: Conforms to SBS standards for microplates.

Atmospheric Control Unit (ACU)

Actively regulates O2 and CO2 - 0.1-20%

Stacker

Magazines for up to 50 plates - continuous loading feature

THERMOstar

Microplate Incubator and Shaker

Optical Filters

Excitation and emission slides for 4 filters each

Upgrades

Please contact your local representative for upgrades including options such as detection modes, reagent injectors, etc.

LOD = 3 x SD (20 blanks) / slope (6 pt std curve)
AlphaScreen® P-Tyr-100 assay kit, PerkinElmer, #6760620C
Microplates: white for LUM, AlphaScreen®, TRF; black for FI, FP; clear for ABS
96 = 96-well microplates
384sv = 384-well small volume microplates
384g = 384-well glass bottom microplates
1536 = 1536-well microplates